{"id":6900331249822,"title":"BioCeuticals Clinical SB Restore 60caps","handle":"bioceuticals-clinical-sb-restore","description":"\u003ch2\u003eBioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eSaccharomyces cerevisiae (boulardii) with Nutrients to Support Epithelial Integrity\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eBioCeuticals Clinical SB Restore is part of the BioCeuticals Clinical Range\u003c\/p\u003e\n\u003cp\u003eAvailable in sizes: 60 capsules\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eProbiotic with nutrients for multifaceted digestive support.\u003c\/li\u003e\n\u003cli\u003eSaccharomyces cerevisiae (boulardii) with Nutrients to Support Epithelial Integrity\u003c\/li\u003e\n\u003cli\u003eBioCeuticals Clinical SB Restore combines Saccharomyces boulardii (SB) with vitamin A, vitamin D, selenium and zinc. SB may aid digestion and help maintain healthy digestive function, zinc and vitamin A may help maintain epithelial integrity, whilst vitamin A, vitamin D, zinc and selenium may assist immune support.\u003c\/li\u003e\n\u003cli\u003eThis vegetarian formula has been designed to provide multifaceted support for the gastrointestinal tract.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBioCeuticals Clinical SB Restore has No Added Dairy, No Added Gluten, Vegetarian Friendly\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Clinical SB Restore AUST L 283003\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDose\u003c\/h5\u003e\n\u003ch2\u003eDose: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003cp\u003eAdults:\u003c\/p\u003e\n\u003cp\u003eTake 1 capsule up to four times daily or as directed by your healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003eTake 2 hours before or 4-6 hours after antifungals.\u003c\/p\u003e\n\u003cp\u003eNot recommended for use in pregnancy without consulting your doctor or pharmacist.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eS boulardii has been clinically trialled in infants and children without any serious side effects reported.\u003c\/li\u003e\n\u003cli\u003eAlthough S. boulardii is a non-pathogenic organism, there is some concern that immunocompromised or critically ill patients taking S. boulardii may have an increased risk for fungaemia.\u003c\/li\u003e\n\u003cli\u003ePatients with long-term dysbiosis may need to start at a lower dose.\u003c\/li\u003e\n\u003cli\u003ePatients with true (IgE-mediated) yeast allergy may be allergic to products containing S. boulardii.\u003c\/li\u003e\n\u003cli\u003eSince S. boulardii is a yeast, antifungal medications\/herbal supplements may decrease its effectiveness.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eFeaturess\u003c\/h5\u003e\n\u003ch2\u003eFeatures: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAids digestion and helps maintain healthy digestive function.\u003c\/li\u003e\n\u003cli\u003eSaccharomyces boulardii (SB) supplementation during and after antibiotic therapy may help to maintain healthy intestinal flora.\u003c\/li\u003e\n\u003cli\u003eSB survives gastric acid and is not inhibited by antibiotics.\u003c\/li\u003e\n\u003cli\u003eSB may reduce the incidence of traveller’s diarrhoea when taken before and during travel.\u003c\/li\u003e\n\u003cli\u003eStability testing has been conducted on this freeze-dried Saccharomyces boulardii product. Data shows that when stored at 25 degrees in 60% relative humidity, the CFU count within the product meets label claim for a minimum of 24 months.\u003c\/li\u003e\n\u003cli\u003eZinc and vitamin A play a role in maintaining the integrity of epithelial tissues, including in the gastrointestinal tract.\u003c\/li\u003e\n\u003cli\u003eVitamins A and D, selenium and zinc play a role in the maintenance of a normal, healthy immune system.\u003c\/li\u003e\n\u003cli\u003eVegetarian, low excipient formula\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIngredient Summary\u003c\/h5\u003e\n\u003ch2\u003eIngredient Summary: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eSaccharomyces boulardii\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSaccharomyces cerevisiae (boulardii), also known as Saccharomyces boulardii (SB) is commonly used in acute conditions, showing effective actions in maintaining a healthy microbiota during antibiotic use1  and reducing the incidence of traveller’s diarrhoea.2 SB increases secretory IgA,3  decreases the expression of pro-inflammatory mediators (nuclear factor-kappa beta (Nf-kB), tumour necrosis factor alpha (TNF-a), interleukin (IL)-6 and IL-8) and increases expression of anti-inflammatory IL-10.4,5\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eGastrointestinal integrity\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSB encourages short-chain fatty acid (SCFA) synthesis and dephosphorylation of lipopolysaccharide.6,7 SB Restore includes vitamin A and zinc to help support intestinal epithelial integrity.\u003c\/p\u003e\n\u003cp\u003eSufficient vitamin A is necessary for normal epithelial barrier function, preventing bacterial translocation across the intestinal mucosa.8 Retinoic acid is required for the differentiation of naïve CD4 T-lymphocytes into induced regulatory T-lymphocytes (Tregs); Tregs are critical for mucosal integrity.9\u003c\/p\u003e\n\u003cp\u003eZinc is also an important nutrient for gastrointestinal integrity. Zinc has been found to impact epithelial barrier function, partly due to modifications of the tight junctions between cells.10\u003c\/p\u003e\n\u003cp\u003eZinc may also be a factor in regulating apoptosis, any alteration of which is likely to cause disrupted epithelial barrier function.11\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eImmune support\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eVitamins A and D, selenium and zinc are included to help maintain the function of a healthy immune system.\u003c\/p\u003e\n\u003cp\u003eVitamin D receptors (VDR) have been found on a number of immune cells, including activated T and B lymphocytes and macrophages.12 VDR also play a critical role in mucosal barrier homeostasis by preserving the integrity of junction complexes.13 The mucosal barrier is the body’s first line of defence against external pathogens14 and is therefore critical for maintaining immunity and gastrointestinal integrity.\u003c\/p\u003e\n\u003cp\u003eSelenium plays a role in antigen stimulation, generation of cytotoxic lymphocytes and increasing natural killer cell activity.15 In animal studies, selenium improved the colonisation and diversity of the gut microbiota;16 the microbiota is understood to maintain the structural integrity of the gut mucosal barrier.17\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/BioCeuticals_Clinical_SB_Restore_60caps_Figure_1_600x600.jpg?v=1629254675\" alt=\"BioCeuticals Clinical SB Restore 60caps Figure 1 Potential mechanisms of action of Saccharomyces boulardii in the intestinal lumen. HealthMasters BioCeuticals Clinical\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSaccharomyces cerevisiae (boulardii)\u003c\/td\u003e\n\u003ctd\u003e250mg (5 billion CFU)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc (as citrate dihydrate)\u003c\/td\u003e\n\u003ctd\u003e7.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eColecalciferol\u003c\/td\u003e\n\u003ctd\u003e6.25mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- equiv. vitamin D3\u003c\/td\u003e\n\u003ctd\u003e250IU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRetinol acetate\u003c\/td\u003e\n\u003ctd\u003e187mcgRE*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- equiv. vitamin A\u003c\/td\u003e\n\u003ctd\u003e625IU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSelenium (as selenomethionine)\u003c\/td\u003e\n\u003ctd\u003e6.25mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e*RE = Retinol equivalents\u003c\/p\u003e\n\u003ch5\u003eFree From\u003c\/h5\u003e\n\u003ch2\u003eFree From: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eNo added dairy.\u003c\/li\u003e\n\u003cli\u003eNo added Gluten.\u003c\/li\u003e\n\u003cli\u003eVegetarian friendly.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003cp\u003eIf symptoms persist consult your healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003eIf diarrhoea persists for more than 6 hours in infants under 6 months, 12 hours in children under 3 years, 24 hours in children aged 3-6 years or 48 hours in adults and children over 6 years, seek medical advice.\u003c\/p\u003e\n\u003cp\u003eIf you are pregnant – or considering becoming pregnant – do not take vitamin A supplements without consulting your doctor or pharmacist. When taken in excess of 3000mcgRE – vitamin A can cause birth defects.\u003c\/p\u003e\n\u003cp\u003eThe recommended daily amount of vitamin A from all sources is 700mcgRE for women and 900mcgRE for men.\u003c\/p\u003e\n\u003cp\u003eContains zinc which may be dangerous if taken in large amounts or for a long period.\u003c\/p\u003e\n\u003cp\u003eThis product contains selenium which is toxic in high doses. A daily dose of B 150mcg for adults of selenium from dietary supplements should not be exceeded.\u003c\/p\u003e\n\u003cp\u003eAlways read the label. Use only as directed.\u003c\/p\u003e\n\u003ch5\u003eCompanion Products\u003c\/h5\u003e\n\u003ch2\u003eCompanion Products: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003cp\u003e\u003cspan\u003eBioCeuticals Clinical SB Restore \u003c\/span\u003e\u003cspan\u003eis associated with: \u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eBioCeuticals Clinical ImmuneForce\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eBioCeuticals Clinical IM Repair\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eBioCeuticals Clinical UB DailyBiota\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eMcFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol 2010;16(18):2202-2222.\u003c\/li\u003e\n\u003cli\u003eKollaritsch HH, Kremasner P, Wiedermann G, et al. Prevention of traveller’s diarrhoea: comparison of different non-antibiotic preparations. Travel Med Int 1989;7:9-18.\u003c\/li\u003e\n\u003cli\u003eUnderdown B, Schiff M. Immunoglobulin A: strategic defense initiative at the mucosal surface. Annu Rev Immunol 1986;4:389-417.\u003c\/li\u003e\n\u003cli\u003eKelesidis T, Pothoulakis C. Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders. Therap Adv Gastroenterol 2012;5(2):111-125.\u003c\/li\u003e\n\u003cli\u003eFitzpatrick LR. Probiotics for the treatment of Clostridium difficile associated disease. World J Gastrointest Pathophysiol 2013;4(3):47-52.\u003c\/li\u003e\n\u003cli\u003ePothoulakis C. Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardii. Aliment Pharmacol Ther 2009;30(8):826-833.\u003c\/li\u003e\n\u003cli\u003eButs JP, Dekeyser N, Stilmant C, et al. Saccharomyces boulardii produces in rat small intestine a novel protein phosphatase that inhibits Escherichia coli endotoxin by dephosphorylation. Pediatr Res 2006;60(1):24-29.\u003c\/li\u003e\n\u003cli\u003eShils ME, Shike M, Ross AC, et al. Modern nutrition in health and disease, 10th edition, 2006. Lippincott Williams \u0026amp; Wilkins: Baltimore.\u003c\/li\u003e\n\u003cli\u003eHigdon J. Vitamin A, 2015. Viewed 9 December 2016, \u003ca href=\"http:\/\/lpi\"\u003ehttp:\/\/lpi\u003c\/a\u003e. oregonstate.edu\/mic\/vitamins\/vitamin-A\u003c\/li\u003e\n\u003cli\u003eSkrovanek S, DiGuilio K, Bailey R, et al. Zinc and gastrointestinal disease. World J Gastro Pathophysiol 2014;5(4):496-513.\u003c\/li\u003e\n\u003cli\u003eMcFarland LV, Dublin S. Meta-analysis of probiotics for the treatment of irritable bowel syndrome. World J Gastroenterol 2008;14(17):2650-2661.\u003c\/li\u003e\n\u003cli\u003eStipanuk MH, Caudill MA. Biochemical, physiological, and molecular aspects of human nutrition, 3rd edition, 2013. Elsevier Saunders: Missouri.\u003c\/li\u003e\n\u003cli\u003eKong J, Zhang Z, Musch MW, et al. Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol 2008;294(1):G208-G216.\u003c\/li\u003e\n\u003cli\u003eFrance MM, Turner JR. The mucosal barrier at a glance. J Cell Sci 2017;130:307-314.\u003c\/li\u003e\n\u003cli\u003eEFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on the substantiation of health claims related to selenium and protection of DNA, proteins and lipids from oxidative damage (ID 277, 283, 286, 1289, 1290, 1291, 1293, 1751), function of the immune system (ID 278), thyroid function (ID 279, 282, 286, 1289, 1290, 1291, 1293), function of the heart and blood vessels (ID 280), prostate function (ID 284), cognitive function (ID 285) and spermatogenesis (ID 396) pursuant to Article 13(1) of Regulation (EC) No 1924\/2006. EFSA J 2009;7(9):1220.\u003c\/li\u003e\n\u003cli\u003eKasaikina MV, Kravtsova MA, Lee BC, et al. Dietary selenium affects host selenoproteome expression by influencing the gut microbiota. FASEB J 2011;25(7):2492-2499.\u003c\/li\u003e\n\u003cli\u003eJandhyala SM, Talukdar R, Subramanyam C, et al. Role of the normal gut microbiota. World J Gastroenterol 2015;21(29): 8787-8803.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c!-- \/TABS --\u003e","published_at":"2022-10-11T14:05:57+11:00","created_at":"2021-08-17T12:29:41+10:00","vendor":"BioCeuticals","type":"BioCeuticals Clinical Naturopathic Medicines","tags":["BioCeuticals Clinical","Naturopathic","PB"],"price":6296,"price_min":6296,"price_max":6296,"available":true,"price_varies":false,"compare_at_price":6995,"compare_at_price_min":6995,"compare_at_price_max":6995,"compare_at_price_varies":false,"variants":[{"id":40554659283102,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"BiCClSBRestore60C","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"BioCeuticals Clinical SB Restore 60caps","public_title":null,"options":["Default Title"],"price":6296,"weight":0,"compare_at_price":6995,"inventory_quantity":10503,"inventory_management":"shopify","inventory_policy":"continue","barcode":"9337896017005","requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/BioCeuticalsClinicalSBRestore60caps10_offRRPatHealthMastersBioCeuticalsClinical.jpg?v=1629255371","\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Bioceuticals-logo_70e6acce-5953-49a1-bbcc-7b522abc9406.jpg?v=1629255306"],"featured_image":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/BioCeuticalsClinicalSBRestore60caps10_offRRPatHealthMastersBioCeuticalsClinical.jpg?v=1629255371","options":["Title"],"media":[{"alt":"BioCeuticals Clinical SB Restore 60caps 10% off RRP at HealthMasters BioCeuticals Clinical","id":22669347553438,"position":1,"preview_image":{"aspect_ratio":0.462,"height":1200,"width":554,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/BioCeuticalsClinicalSBRestore60caps10_offRRPatHealthMastersBioCeuticalsClinical.jpg?v=1629255371"},"aspect_ratio":0.462,"height":1200,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/BioCeuticalsClinicalSBRestore60caps10_offRRPatHealthMastersBioCeuticalsClinical.jpg?v=1629255371","width":554},{"alt":"BioCeuticals Clinical SB Restore 60caps 10% off RRP at HealthMasters BioCeuticals Clinical Logo","id":22651536146590,"position":2,"preview_image":{"aspect_ratio":4.656,"height":302,"width":1406,"src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Bioceuticals-logo_70e6acce-5953-49a1-bbcc-7b522abc9406.jpg?v=1629255306"},"aspect_ratio":4.656,"height":302,"media_type":"image","src":"\/\/shop.healthmasters.com.au\/cdn\/shop\/products\/Bioceuticals-logo_70e6acce-5953-49a1-bbcc-7b522abc9406.jpg?v=1629255306","width":1406}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch2\u003eBioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eSaccharomyces cerevisiae (boulardii) with Nutrients to Support Epithelial Integrity\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eBioCeuticals Clinical SB Restore is part of the BioCeuticals Clinical Range\u003c\/p\u003e\n\u003cp\u003eAvailable in sizes: 60 capsules\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eProbiotic with nutrients for multifaceted digestive support.\u003c\/li\u003e\n\u003cli\u003eSaccharomyces cerevisiae (boulardii) with Nutrients to Support Epithelial Integrity\u003c\/li\u003e\n\u003cli\u003eBioCeuticals Clinical SB Restore combines Saccharomyces boulardii (SB) with vitamin A, vitamin D, selenium and zinc. SB may aid digestion and help maintain healthy digestive function, zinc and vitamin A may help maintain epithelial integrity, whilst vitamin A, vitamin D, zinc and selenium may assist immune support.\u003c\/li\u003e\n\u003cli\u003eThis vegetarian formula has been designed to provide multifaceted support for the gastrointestinal tract.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBioCeuticals Clinical SB Restore has No Added Dairy, No Added Gluten, Vegetarian Friendly\u003c\/p\u003e\n\u003cp\u003eBioCeuticals Clinical SB Restore AUST L 283003\u003c\/p\u003e\n\u003c!-- TABS --\u003e\n\u003ch5\u003eDose\u003c\/h5\u003e\n\u003ch2\u003eDose: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003cp\u003eAdults:\u003c\/p\u003e\n\u003cp\u003eTake 1 capsule up to four times daily or as directed by your healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003eTake 2 hours before or 4-6 hours after antifungals.\u003c\/p\u003e\n\u003cp\u003eNot recommended for use in pregnancy without consulting your doctor or pharmacist.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eS boulardii has been clinically trialled in infants and children without any serious side effects reported.\u003c\/li\u003e\n\u003cli\u003eAlthough S. boulardii is a non-pathogenic organism, there is some concern that immunocompromised or critically ill patients taking S. boulardii may have an increased risk for fungaemia.\u003c\/li\u003e\n\u003cli\u003ePatients with long-term dysbiosis may need to start at a lower dose.\u003c\/li\u003e\n\u003cli\u003ePatients with true (IgE-mediated) yeast allergy may be allergic to products containing S. boulardii.\u003c\/li\u003e\n\u003cli\u003eSince S. boulardii is a yeast, antifungal medications\/herbal supplements may decrease its effectiveness.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eFeaturess\u003c\/h5\u003e\n\u003ch2\u003eFeatures: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAids digestion and helps maintain healthy digestive function.\u003c\/li\u003e\n\u003cli\u003eSaccharomyces boulardii (SB) supplementation during and after antibiotic therapy may help to maintain healthy intestinal flora.\u003c\/li\u003e\n\u003cli\u003eSB survives gastric acid and is not inhibited by antibiotics.\u003c\/li\u003e\n\u003cli\u003eSB may reduce the incidence of traveller’s diarrhoea when taken before and during travel.\u003c\/li\u003e\n\u003cli\u003eStability testing has been conducted on this freeze-dried Saccharomyces boulardii product. Data shows that when stored at 25 degrees in 60% relative humidity, the CFU count within the product meets label claim for a minimum of 24 months.\u003c\/li\u003e\n\u003cli\u003eZinc and vitamin A play a role in maintaining the integrity of epithelial tissues, including in the gastrointestinal tract.\u003c\/li\u003e\n\u003cli\u003eVitamins A and D, selenium and zinc play a role in the maintenance of a normal, healthy immune system.\u003c\/li\u003e\n\u003cli\u003eVegetarian, low excipient formula\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eIngredient Summary\u003c\/h5\u003e\n\u003ch2\u003eIngredient Summary: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eSaccharomyces boulardii\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSaccharomyces cerevisiae (boulardii), also known as Saccharomyces boulardii (SB) is commonly used in acute conditions, showing effective actions in maintaining a healthy microbiota during antibiotic use1  and reducing the incidence of traveller’s diarrhoea.2 SB increases secretory IgA,3  decreases the expression of pro-inflammatory mediators (nuclear factor-kappa beta (Nf-kB), tumour necrosis factor alpha (TNF-a), interleukin (IL)-6 and IL-8) and increases expression of anti-inflammatory IL-10.4,5\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eGastrointestinal integrity\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eSB encourages short-chain fatty acid (SCFA) synthesis and dephosphorylation of lipopolysaccharide.6,7 SB Restore includes vitamin A and zinc to help support intestinal epithelial integrity.\u003c\/p\u003e\n\u003cp\u003eSufficient vitamin A is necessary for normal epithelial barrier function, preventing bacterial translocation across the intestinal mucosa.8 Retinoic acid is required for the differentiation of naïve CD4 T-lymphocytes into induced regulatory T-lymphocytes (Tregs); Tregs are critical for mucosal integrity.9\u003c\/p\u003e\n\u003cp\u003eZinc is also an important nutrient for gastrointestinal integrity. Zinc has been found to impact epithelial barrier function, partly due to modifications of the tight junctions between cells.10\u003c\/p\u003e\n\u003cp\u003eZinc may also be a factor in regulating apoptosis, any alteration of which is likely to cause disrupted epithelial barrier function.11\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eImmune support\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003eVitamins A and D, selenium and zinc are included to help maintain the function of a healthy immune system.\u003c\/p\u003e\n\u003cp\u003eVitamin D receptors (VDR) have been found on a number of immune cells, including activated T and B lymphocytes and macrophages.12 VDR also play a critical role in mucosal barrier homeostasis by preserving the integrity of junction complexes.13 The mucosal barrier is the body’s first line of defence against external pathogens14 and is therefore critical for maintaining immunity and gastrointestinal integrity.\u003c\/p\u003e\n\u003cp\u003eSelenium plays a role in antigen stimulation, generation of cytotoxic lymphocytes and increasing natural killer cell activity.15 In animal studies, selenium improved the colonisation and diversity of the gut microbiota;16 the microbiota is understood to maintain the structural integrity of the gut mucosal barrier.17\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2075\/8503\/files\/BioCeuticals_Clinical_SB_Restore_60caps_Figure_1_600x600.jpg?v=1629254675\" alt=\"BioCeuticals Clinical SB Restore 60caps Figure 1 Potential mechanisms of action of Saccharomyces boulardii in the intestinal lumen. HealthMasters BioCeuticals Clinical\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003ch2\u003eIngredients: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003ctable width='100%\"'\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEach capsule contains:\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSaccharomyces cerevisiae (boulardii)\u003c\/td\u003e\n\u003ctd\u003e250mg (5 billion CFU)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eZinc (as citrate dihydrate)\u003c\/td\u003e\n\u003ctd\u003e7.5mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eColecalciferol\u003c\/td\u003e\n\u003ctd\u003e6.25mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- equiv. vitamin D3\u003c\/td\u003e\n\u003ctd\u003e250IU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRetinol acetate\u003c\/td\u003e\n\u003ctd\u003e187mcgRE*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e- equiv. vitamin A\u003c\/td\u003e\n\u003ctd\u003e625IU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSelenium (as selenomethionine)\u003c\/td\u003e\n\u003ctd\u003e6.25mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e*RE = Retinol equivalents\u003c\/p\u003e\n\u003ch5\u003eFree From\u003c\/h5\u003e\n\u003ch2\u003eFree From: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eNo added dairy.\u003c\/li\u003e\n\u003cli\u003eNo added Gluten.\u003c\/li\u003e\n\u003cli\u003eVegetarian friendly.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eWarnings\u003c\/h5\u003e\n\u003ch2\u003eWarnings: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003cp\u003eIf symptoms persist consult your healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003eIf diarrhoea persists for more than 6 hours in infants under 6 months, 12 hours in children under 3 years, 24 hours in children aged 3-6 years or 48 hours in adults and children over 6 years, seek medical advice.\u003c\/p\u003e\n\u003cp\u003eIf you are pregnant – or considering becoming pregnant – do not take vitamin A supplements without consulting your doctor or pharmacist. When taken in excess of 3000mcgRE – vitamin A can cause birth defects.\u003c\/p\u003e\n\u003cp\u003eThe recommended daily amount of vitamin A from all sources is 700mcgRE for women and 900mcgRE for men.\u003c\/p\u003e\n\u003cp\u003eContains zinc which may be dangerous if taken in large amounts or for a long period.\u003c\/p\u003e\n\u003cp\u003eThis product contains selenium which is toxic in high doses. A daily dose of B 150mcg for adults of selenium from dietary supplements should not be exceeded.\u003c\/p\u003e\n\u003cp\u003eAlways read the label. Use only as directed.\u003c\/p\u003e\n\u003ch5\u003eCompanion Products\u003c\/h5\u003e\n\u003ch2\u003eCompanion Products: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003cp\u003e\u003cspan\u003eBioCeuticals Clinical SB Restore \u003c\/span\u003e\u003cspan\u003eis associated with: \u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eBioCeuticals Clinical ImmuneForce\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eBioCeuticals Clinical IM Repair\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eBioCeuticals Clinical UB DailyBiota\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003ch2\u003eReferences: BioCeuticals Clinical SB Restore\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eMcFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol 2010;16(18):2202-2222.\u003c\/li\u003e\n\u003cli\u003eKollaritsch HH, Kremasner P, Wiedermann G, et al. Prevention of traveller’s diarrhoea: comparison of different non-antibiotic preparations. Travel Med Int 1989;7:9-18.\u003c\/li\u003e\n\u003cli\u003eUnderdown B, Schiff M. Immunoglobulin A: strategic defense initiative at the mucosal surface. Annu Rev Immunol 1986;4:389-417.\u003c\/li\u003e\n\u003cli\u003eKelesidis T, Pothoulakis C. Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders. Therap Adv Gastroenterol 2012;5(2):111-125.\u003c\/li\u003e\n\u003cli\u003eFitzpatrick LR. Probiotics for the treatment of Clostridium difficile associated disease. World J Gastrointest Pathophysiol 2013;4(3):47-52.\u003c\/li\u003e\n\u003cli\u003ePothoulakis C. Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardii. Aliment Pharmacol Ther 2009;30(8):826-833.\u003c\/li\u003e\n\u003cli\u003eButs JP, Dekeyser N, Stilmant C, et al. Saccharomyces boulardii produces in rat small intestine a novel protein phosphatase that inhibits Escherichia coli endotoxin by dephosphorylation. Pediatr Res 2006;60(1):24-29.\u003c\/li\u003e\n\u003cli\u003eShils ME, Shike M, Ross AC, et al. Modern nutrition in health and disease, 10th edition, 2006. Lippincott Williams \u0026amp; Wilkins: Baltimore.\u003c\/li\u003e\n\u003cli\u003eHigdon J. Vitamin A, 2015. Viewed 9 December 2016, \u003ca href=\"http:\/\/lpi\"\u003ehttp:\/\/lpi\u003c\/a\u003e. oregonstate.edu\/mic\/vitamins\/vitamin-A\u003c\/li\u003e\n\u003cli\u003eSkrovanek S, DiGuilio K, Bailey R, et al. Zinc and gastrointestinal disease. World J Gastro Pathophysiol 2014;5(4):496-513.\u003c\/li\u003e\n\u003cli\u003eMcFarland LV, Dublin S. Meta-analysis of probiotics for the treatment of irritable bowel syndrome. World J Gastroenterol 2008;14(17):2650-2661.\u003c\/li\u003e\n\u003cli\u003eStipanuk MH, Caudill MA. Biochemical, physiological, and molecular aspects of human nutrition, 3rd edition, 2013. Elsevier Saunders: Missouri.\u003c\/li\u003e\n\u003cli\u003eKong J, Zhang Z, Musch MW, et al. Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol 2008;294(1):G208-G216.\u003c\/li\u003e\n\u003cli\u003eFrance MM, Turner JR. The mucosal barrier at a glance. J Cell Sci 2017;130:307-314.\u003c\/li\u003e\n\u003cli\u003eEFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on the substantiation of health claims related to selenium and protection of DNA, proteins and lipids from oxidative damage (ID 277, 283, 286, 1289, 1290, 1291, 1293, 1751), function of the immune system (ID 278), thyroid function (ID 279, 282, 286, 1289, 1290, 1291, 1293), function of the heart and blood vessels (ID 280), prostate function (ID 284), cognitive function (ID 285) and spermatogenesis (ID 396) pursuant to Article 13(1) of Regulation (EC) No 1924\/2006. EFSA J 2009;7(9):1220.\u003c\/li\u003e\n\u003cli\u003eKasaikina MV, Kravtsova MA, Lee BC, et al. Dietary selenium affects host selenoproteome expression by influencing the gut microbiota. FASEB J 2011;25(7):2492-2499.\u003c\/li\u003e\n\u003cli\u003eJandhyala SM, Talukdar R, Subramanyam C, et al. Role of the normal gut microbiota. World J Gastroenterol 2015;21(29): 8787-8803.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c!-- \/TABS --\u003e"}